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ea0029p1566 | Thyroid (non-cancer) | ICEECE2012

Response to high dose glucocorticoid therapy in patients with dysthyroid optic neuropathy (DON)

Covelli D. , Vannucchi G. , Curro N. , Campi I. , Guastella C. , Pignataro L. , Peccoz P Beck , Salvi M.

Dysthyroid optic neuropathy (DON) is a sight threatening complication occurring in 35% patients with Graves orbitopathy. The medical treatment consists in the infusion of high dose of methylprednisolone (MP), while surgical orbital decompression is mandatory in patients non responding to the medical treatment. We aimed at studying the response to high dose steroids in DON and parameters for predicting therapy effectiveness. Twenty-three patients with DON were studi...

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ea0029p1594 | Thyroid (non-cancer) | ICEECE2012

Enhanced expression of the B cell activation factor (BAFF) and baff-receptor (BAFF-R) in the thyroid and in the orbital adipose tissue from patients with graves’ disease (GD) and associated orbitopathy (GO)

Campi I. , Vannucchi G. , Covelli D. , Rossi S. , Doi P. , Curro N. , Pignataro L. , Guastella C. , Beck-Peccoz P. , Salvi M.

BAFF, a member of the TNF family, promotes autoantibody production by increasing B cell survival and proliferation. We have previously shown that serum BAFF concentrations are increased in GD patients. In the present work, we studied the expression of BAFF and BAFF-R, by immunohistochemistry (IHC) on paraffin embedded sections of: 1. orbital adipose tissue from 22 patients (5 men, 17 women) with GO (3 of them with active GO) associated with GD or Hashimoto thyroiditis in 19 an...

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Endocrine Abstracts

Response to high dose glucocorticoid therapy in patients with dysthyroid optic neuropathy (DON)

Enhanced expression of the B cell activation factor (BAFF) and baff-receptor (BAFF-R) in the thyroid and in the orbital adipose tissue from patients with graves’ disease (GD) and associated orbitopathy (GO)

BiosciAbstracts